The S2, just like any other piece of mining hardware, is affected by the same set of factors: how much it costs to run it, how much coin it generates, how much the coin is worth. If the circumstances at the time of the halving are such that the profit made from the mined coin is higher than the expenses for mining them, then it'll still be profitable. Nobody can predict the future, so nobody can really answer your question.
However, at the current levels... that S2 expects to make 0.009846
BTC or ~$2.80 a day. It pulls 1100W from the wall. At $0.10 per kWh, the S2 is costing you $2.64 to run... so you're still squeaking out a profit
.