Dropping the memory too low (And on certain SDK's) can cause a drop in mh/s, Most cards have a "butter zone" where you'll get a magical bonus 2mh/s, And lose it if you stray out of the zone. For most cards it's around 350/410
https://en.bitcoin.it/wiki/Mining_hardware_comparison Here you can find some settings to try from
I would try Vectors 1, W 128, Poclbm kernal.
Or, Vectors 1, W 256, Diablo Kernal
You can edit all these settings in the CGminer configuration file