Now if the idea behind 2FA is that just a password is not enough security, it seems that having backups emailed to me partially defeats the purpose of 2FA in the first place, since the 2FA will do nothing for someone that may intercept a copy of the encrypted wallet file.
Correct. The 2FA is to protect against a replay attack using your password to access the Blockchain.info website. It does not protect the backups.
Someone with your blockchain.info/wallet password and access to the encrypted wallet file can decrypt the file and spend your funds. [Edit: If you have your account configured with a second password for withdrawals, then that password is required as well in order to decrypt and spend the funds.]