It would be tedious to write as you couldn't use numbers. Excel uses floats.
BIN2DEC() only supports 10 bits. HEX2DEC() only supports 40 bits.
even n = 115792089237316195423570985008687907852837564279074904382605163141518161494337 pasted into a cell:
1.15792089237316E+77
This guy made a spreadsheet that does SHA256 of some text, which is already impressive. It has about 80 sheets of formulas.
https://bitcointalk.org/index.php?topic=809430.0