There are different P2Pool implimentations, the ones I know specifically about are SHA256 based (any coin using that algorythm like BitCoin) and Scrypt (Litecoin/Doge/etc) - you have to set up a wallet for each coin then set up your P2Pool node to point at each wallet.
You can point it at multiple wallets at the same time, allowing for merge mining - but you have to set one coin up specifically as your "primary" with the others being merge mined.
I think I remember there being an X11-based version as well, but never got serious enough about non-DASH (Darkcoin at the time) coins to look into that option.
I still would need someone to set it up for me or make a easy to fallow video I really am having problems with that program. I would pay you if I can get my pc set up.