According to this article,
http://www.sfgate.com/news/article/Nevada-Legislature-passes-online-gambling-law-4297758.php, Nevada has now just opened a pathway to legalizing internet gambling in the US.
If Nevada can successfully get other states on board as "partner states", then a gambling network that can operate from Nevada, but allow players from all "partner states", could come online. Theoretically, this would allow a proper, legal venue for gambling with Bitcoins. If such a thing were to come to fruition, I imagine it would be possible for a chain-style of business to open in each "partner state" that would act like an internet-cafe where players could come in, buy bitcoins with cash, sit at a computer, and gamble online playing numerous types of games.
This is all, of course, if Nevada can get other states to partner with it. Still though, it's a very interesting revelation that some should pay close attention to. I know $500,000 seems like a lot for a license, but in all reality, the potential for profit would be ridiculous, and I'm sure the backers of SatoshiDice wouldn't think for half a second about dropping that kind of cash.