Ubunto and debian seem to work nice. Just be careful what drivers you use on your cards. trust me it makes a huge difference.
Ive actually found that windows works best cause the drivers and SDK are better. Im still messing around tho
![Smiley](https://bitcointalk.org/Smileys/default/smiley.gif)
No, don't even use Ubuntu. Unity is good, but it'll eat your resource (Unity is built in with compiz). But *buntu family like Xubuntu or Lubuntu is fine though.