I don't think the 4850 is worth bothering with tbh, but yes they should work together fine. I've ran a mix of 5870/5970 & 6990s together without issues.
Thought I read some issue with 5/6 series cards and 7 series cards together? Maybe I'm mistaken.
(Not concerned about hash rate right now, honestly, just diddling around and learning)
There may well be, I'm sorry I only have experience with 5/6 series cards.
Hopefully someone more knowledgeable can chime in.