so, what wallet would be best, and is it possible to have the device ask me for hardware button confirmation when i use the desktop wallet? i tried it on multibit HD but it doesnt ask for it, only when i use the ledger chrome app...
Ledger nano S is designed to work with Ledger Wallet Bitcoin & Ethereum and Copay
As seen from here
https://www.ledgerwallet.com/products/12-ledger-nano-s I don't believe that the ledger nano S can be integrated in any desktop wallet and use its button to confirm a transaction.
To be more secure you probably should research about the 2FA instead of a third party hardware buttons.