I have 5 rigs with 8 GPU's each (Some are dual GPU cards). 5850, 5870, 5970s. Z77A-G45 or 890FX-GD70, PCI-E 1x risers, Seasonic x-1250 or Rosewill Lightning 1300w or OCZ ZX 1250W or SPI Magna Pro Gold 1200w, Win7 x64, Driver 11.12, SDK 2.1 plus SDK 2.5 (SDK 2.1 is whats mined on, 2.4+ is required for 2.1 to even be detected and useable), bfgminer, phatk, vectors 2, worksize 128, intensity 11, 1 gpu thread, roughly 1 memory MHz for every 5 core MHz.
Image is clickable for higher res. I just set it up yesterday, I'll clean up the wires later.
Screenshot of bottom right rig's mining software in operation.