yea like chronek said if you use the new AMD drivers they have drivers signing turned on now and it looks likes that gonna sty so those drivers with only work if you replace and patch the atikmdag.sys file with the atikmdag-patcher-1.4.3 or go back to the original bios which can be found here
https://anorak.tech/ or don't use the new drivers at all if you want to use your molded bios and don't want to patch it unless they turn off drivers signing and sadly at some point in time you may have to use the newer drivers with stock bios or patch it, if they don't block that .
and depending on the AMD card the 15.12 drivers don't have RX 400 series support I tired to install them with my RX 400 series cards they didn't work and the release notes don't list the RX 400 series as supported cards, but you may be able to add support, if you look around, i read some place, some were able to . me i would rather use whats new from past usages using old drivers with new gear it just didn't cut it for me, unless the new drivers had major bugs
Here is the how to if you don't mind Patching the new drivers with file links that explains it all . the new drivers work fine for some and for others there a nite mare .
https://www.techpowerup.com/228536/amd-bios-signature-check-re-enabled-with-relive-locks-out-polaris-bios-modders