Imagine to yourself how many wallet with astronomic sums of bitcoin people lost or lost because they didnt give a fuck when bitcoin was tiny.
and those wallets..will never get acceesable
There's a chance that most of those wallets don't have all that much stuck inside them right now, maybe in the ballpark of a few millions of dollars lost but I find it unlikely that there is much else inside of them since a ton of people would do a lot to get their stuff back.
As mentioned before though, those instances are good because they reduce the supply without changing the demand. That's a good thing in business, since prices go up.