I did a wire transfer to BTC-e, the first transfer worked without incident.
Two weeks later, however, I elected to send a second wire transfer. I had BTC-e's payment details saved in my web banking, and merely had to verify their details on BTC-e's deposit page, as well as, insert reference details, into the transaction. Everything was, and still is, perfect about this transaction; I've checked it many times; and my bank claims that the wire was a success. Despite this, the payment was miraculously lost. It has, thus far, been over a month, and has not been credited to my BTC-e account!
BTC-e will not respond to me at all. I feel that I have been completely reasonable and respectful with BTC-e, and it seems quite unreasonable that they would choose to merely cut me off as soon as I present an inconvenience.
For these reasons, I think it would be a mistake for anyone to trust BTC-e, especially when it comes to depositing funds with them. If anything does go wrong, you can expect them to merely abandon you!
I do think that it is not safe anymore to deal with BTC-e. You'll be absolutely astounded at the scam accusation section of this forum, and how many BTC-e complaints there are out there in this section in question.
Since they don't have any sort of mobile number/landline for you to call, your only chance of getting your money back is to try to get as much attention as possible. Keep requesting for your deposit to be credited on the trollbox(will probably get you banned), keep trying to reach their support even though it seems unlikely they will respond. In the end they'll probably resolve it, they're just really slow with things.
Good luck!