But loosing 1 bitcoin in the ocean of a maximum of 21.000.000 coins seems significant to me, so not comparable to gold and jewelry.
So only 21000 losses of 1000 coins can happen. That's not much!
But remember that each bitcoins can be divided into 100 million pieces, as needed.
And the more valuable they become, the more careful people will be not to lose them.
AMEN!
By the time 1,000,000 coins have been lost, one coin might be worth $1,000,000
People don't tend to lose $1,000,000 worth of anything very often. There will forever be 20 million+ BTC in existence.
IMO if things continue to progress well it'll get harder and harder for people to lose coins as there will always be more and more technological innovation happening to prevents this.