Based in Delaware, the largest cryptocurrency exchange, Poloniex, has updated the terms of use its services. This is reported on the website of the exchange.
According to paragraph 1 of the updated Terms, exchange provides its services to residents of countries which are not a resident of US Department of Commerce:
You represent and warrant that you are not: (a) located in, under the control of, or a national or resident of any country to which the United States has embargoed goods or services, (b) identified as a "Specially Designated National,” or (c) placed on the Commerce Department's Denied Persons List. You further represent and warrant that you will not use the Site if the laws of your country prohibit you from doing so in accordance with these Terms...
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https://bit.news/eng/new-poloniex-terms-provide-for-renunciation-of-collective-lawsuits-against-the-exchange/