As of today
Bitcoin - very safe
Litecoin - safe
DGC - Potential to be THE next alt-coin. However too soon to tell. At least safe to mine as long as profitability on coinchoose is >100%. If profitability stays over 100% as a effect of increase in price (and not decrease in difficulty) for next few days then definitely a winner in my opinion.
YAC - Not sure what the profitability is at the moment as it is not on coinchoose but do your math and if you have free cpu definitely worth a go. No go if you have a decent GPU only OR dont have a decent cpu.
All other coins announced lately - Check which phase they are at of the pump and dump cycle.
1. Coin launched.
2. Coin pre-mined.
3. Coin on exchange.
4. Coin dumped by miners.
5. Profitability below 100% and falling. Check the reason for fall in profitability. If profitability is falling due to prices going down then its almost dead. If prices go down + profitability goes down + difficulty goes down. its definitely DEAD.
6. Cycle is over. move on to another pump and dump coin and mine it till it hit the exchange.
Hope it helps.
Cebb hits the nail on the head with that one.