Also, is there an advantage of going with the MB's that support 12 - 19 GPUs instead of just buying PCI-E 4 in 1 risers that work with any Motherboard? Do GPUs suffer performance wise from having 4 GPUs share a single PCI-E x1 slot instead of having a dedicated PCI-E x1 slot each?
The advantage to going with motherboards that support 12+ GPUs is that those exist.
PCIe 4-in-1 risers that work with "any motherboard" do not exist. Moreover, trying to use several on the same motherboard is asking for setup headaches, unless you happen to get exceedingly lucky with your choice of motherboards.
For mining on the vast majority of algorithms, PCIe bandwidth will make no measurable difference.
Another thing to consider is that more than 12 cards in one rig might not be desirable, as it is quite a large number of eggs in the same basket.