..eak loaded with no saved profiles or settings. It just opened with setting and profile from the installation.
It's a known problem (check Google). I've had it too. Even playing with the settings (as described in the many topics) did not work.
In the end I was fed up and I deleted Tweak. Never had that problem with Afterburner.
Be sure to write down your OC settings on a piece of paper. Always keep backups of your system, wallets, settings... All downtime is costing you money. Just a tip.