www.whattomine.comenter your hardware details in here and mine the most profitable coin
thats it
While that is a good place to start, usually the coins listed aren't the most profitable. My process is generally going to the Announcements thread for altcoins and picking up a new, exciting coin with a new algorithm that the default whattomine page doesn't display. Currently, I'm getting unbelievable profits on the Zero blockchain (with Nvidia cards).