How do you think with this motherboard - ASUS PRIME B250-PLUS, there will be problems?
I want that 4 GPU steadily worked.
IMO, that's a good choice for only 4 GPU on it. It seems you prepare for stability instead quantity, I like this decision. Since mining needs stability for a long term. Many people try to get 7+ PCIe socket on MOBO, but it will be needed extra time for watching and maintenance.