I'm pretty sure that's F, not C. And you typically run the simulation until the die reaches its temperature limit to see how much power is being dissipated when you hit it and what can be improved. For example, if the die hits 100C and the heat sink is only a few degrees above ambient, you know that air flow isn't worth improving.
When rating a cooling solution, the big question you want answered is -- how many watts can my die generate without hitting its limit? Good solutions make that number high. Bad ones make it low. So that's the condition you want to analyze.
An air cooled system simulation with intake air below freezing? Is this a simulation for running bitcoin miners in Antarctica?