Whenever you are going to ask another IT guy about his antivirus preferences he, most likely, will name different antivirus software. As far as your choosen antivirus software has all the features you need it will most likely be good.
For all antivirus i know there is not much to be done after installation and activation. You should sometimes check if it’s doing antivirus definition updates and also a complete antivirus scan (once per week) should be fine.
It's not just that about antivirus programs, every person has something they personally like or something they are paid to promote. From my personal experience (and I’ve tried most AV programs) I would recommend Norton Security as a security solution for home users. Of course, such software comes at a price - but one should never look at investing in security as an unnecessary expense. In the case of Norton, everything is automated, there is no need to run anything manually - weekly quick scan, computer maintenance in terms of performance and disk defragmentation. What I would still recommend is Malwarebytes Premium, certainly one of the best proactive protection programs that includes ransomware protection.
With regular OS updates and smart internet usage most users should be safe from those most common threats, especially considering that crypto users are one of the most vulnerable groups.
As for the antivirus and since I am using Windows, I think it is enough to just use Windows Defender instead of any other third party applications that can be found on the internet. It would just make your system far more insecure. Is it not?
Some even say that any use of AV is completely unnecessary, but it is a matter of their choice. I don't see how using respectable AVs can make the OS more insecure? On the other hand, there are many objections to the W10 as the nightmare of privacy - and yet the WD is something that should be enough to protect your device?