It does claim to be more secure and other Linux distributions although if you look around it's been criticized for being over complicated and not user friendly. SELinux acts sort of like a firewall and as a core is a great idea and should be more secure than the standard Linux distributions although getting it to work has been very difficult for me. The tools that come with it simply aren't very user friendly and it takes hours at times just to perform a simple task.
I'm experienced in Linux and have been using it for many years but I found SE very difficult. I guess it all depends on what you are using it for. I know you've said that you will be hosting a full node on it. But will you be storing any coins on it? If you are only storing the full node and that's all the computer will be used for it's probably not worth it. It would be overkill and you probably don't need a ultra secure node. On the other hand if you are storing a large amount of coins or even enough that you think need to be secured then you could try out SElinux. Although I would recommend just storing any coins separate from a full node and just fun a full node after all you are helping the bitcoin network out by running it! Of course if you are suspicious of your government or how they spy on you then remember that it was created by the NSA...
If you like to learn then SElinux is a great choice it's more secure and is a challenge to learn. I didn't give up on it and have a computer running it. One of the best resources of learning it for me was a coloring book (yes a childs plaything) if you do decide on using it and learning it I would suggest taking a look at it:
https://people.redhat.com/duffy/selinux/selinux-coloring-book_A4-Stapled.pdfIt tries to simplify SELinux with the usage of images to understand it pretty neat way of going about it I think.
