Hello adamantasaurus,
If you want more detailed advise on running a masternode, you should mention which coin you are going to run a masternode for. The methods and details of how to exactly run a masternode differ from coin to coin. For example with Dash you don't need to keep your wallet opened but you should have the masternode software running 24/7. Even though methods vary from coin to coin, most masternodes can be run through VPS servers from a third-party website or a raspberry pi. These methods make it possible to not have your personal computer on at all times. Again we suggest you look for options specific to the coin you are running a Masternode for.
With kind regards,
The Anycoin Direct team
Hey thanks alot for the reply, I just setup masternodes on a VPS for ORE and SOCIALSEND. SO I assume that with the vps I don't need my walet open? Just want to make sure.