Short answer, no not really.
Longer answer, you need to obviously have the slot for a pci-express slot (PCIe) for the graphic card, multiple if you want to have expandability for the future. You can use a minimal processor, minimal ram for whatever OS you're using, and don't even need a disk if you launch from CD/USB stick! As long as the board has the express slots for the card to run and the power supply can handle the card, that's about the bare essentials other than a case and fan that can keep it/them cool!
Agree