As long as you have the proper power supply connections (you should) and a motherboard with 2+ PCI Express slots (which yours has), the hardware angle will be simple - plug both cards in, attach auxiliary power, turn on pc!
Every OS I know of should be perfectly fine with this configuration.
Thx mate, asking because I've never done this before, I'm crossfiring my card actually but this case is not the same haha =D
@Mahkul : I've been mining for 2 weeks, so I know how to deal with software side, just did not know how to deal with hardware side ^^ , I'm using win 7 64 bit mate.