The fact is that even though they've done a good job with security, the chances of Coinbase themselves freezing one's account, or being infiltrated internally, is far greater than having any hacker ever penetrate even a moderately protected paper wallet, generated offline by any average Joe.
I guess for these institutional investors, they are stuck with this as one of the only options. But to me, holding the private keys myself is far more secure than having a third party holding it for me, regardless of the level of security they are at.
It's only little people who'd have to worry about being frozen by Coinbase, but I do wonder how much research the big knobs parking money with them have done.
Their cold storage is completely uninsured, it's only the 2% of funds they have online that are insured for hacks at their end, though I really wouldn't want to see that insurance put to the test.
Coinbase in effect are asking people to entrust untold billions to their noodly little techniques that their customers may not understand in the slightest. I'm sure they're the best techniques but it's a pretty unusual state of affairs.