Daniel Negreanu was known for being good at poker, Winner of six World Poker Series (WSOP) bracelets and two World Poker Tour (WPT) titles. The poker ranking service Global Poker Index recognized Daniel Negreanu as the best poker player of the year 2014. What if he plays poker in a btc-based gambling site, will he manage to defeat an algorithm and bring a lot of profit?
What do you mean by defeating the algorythm? Is there a certain skill that can help you know what card will be delt next? You don't play online poker with strategy to beat the RNG. This is ridiculous if someone has that approach.
What you are suggesting is that anyone, in order to profit online, must cheat the RNG algorythm otherwise he is doomed as every crypto poker room will cheat him.
If this is the case why you ask if he has any chance to profit? Obviously if he plays against a person that can cheat by looking into his cards or having rigged the RNG then noone can beat the cheater.
While gambling with poker online you need to put a lot of trust to the party and the staff involved that provide the game.