For long term, there is no doubt that only maximizing satoshi would give us profits because the increasing price with time would also increase the value for satoshi. If ever the bull runs make bitcoins go to moon that the price for single satoshi might even be compared to a dollar so it might be most important to consider the satoshis we have for holding them in long run.
When the price is big enough and the satoshi is actually a decent amount (you can even say one million satoshi if you want, so we don't know what it means for the satoshi value) that is becoming hundreds of dollars or even thousands of dollars if you mean a lot more. It is impossible to think that one person will not care for that much amount of money, everyone would even if you are rich enough to spend that on a dinner.
However when it comes to finances there is no little amount, even 1 satoshi is a great profit if you profit as long as you do not lose money at all. There was a bot years ago that was working super fast and aiming at profiting 1+ satoshi profit, it was working to make thousands of profits like that per day to combined bigger profit instead of making 1%+ profits constantly. That bot didn't end up doing what it was suppose to but that is exactly what everyone should aim at.
