In my honest opinion, I always trade-in BTC pairs. Regardless of what the price of BTC is, I always want to increase my BTC stash by trading in alts, though sometimes I got into a little trouble with some poor choices of altcoins but when they get pumped they rewarded me nicely. I am a firm believer of the BTC and the price will go up sooner or later so increasing my holdings will be a great thing to see and have.
Depends on what you want to make more from, because if you want to make more dollars then you should trade with USD, depends on which one you want but I prefer BUSD honestly because I trust Binance more than I trust Tether, that should be the case for everyone as well, who the hell is Tether against a place like Binance.
However if your aim is to make more BTC that means you should trade with BTC pairs in order to gain more BTC. That is the mindset because if you want more of one thing, you should focus on that thing and if you focus on another thing you get that, it is not about how much you make it is about what you make. I prefer to make more crypto and that is why I trade depending on getting more of that crypto, it is not bitcoin nor usd for me, I like BNB and because of that I trade with a lot more BNB pairs to make more of that and it has worked out awesome for me recently.
