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I've created some very very few NFTs on opensea.
For someone with 0 idea on how the whole thing works, it's dead ass easy; you upload whatever you want to nft, select the price and a few other stuff and it's ready to be minted.
The problem I mostly faced? Fees. Yeah, they come together with the ETH network; but they give you the chance to create NFTs at 0 fees using the polygon network. And this is where I see a problem (as with altcoins). You are basically using a lot of different blockchains for different porpuses, segregating whatever crypto you may have and making it a pain in the ass to then unite it all in the same network and wallet.
That's however something personal I don't like and actually hate. I like having it simple with just my btc sending btc and having fees in btc.
I was using metamask during the whole process, everything was actually easy to connect and stuff (but, with what I've just said)