Is running a node a profitable crypto business in today's economy? I've seen several videos on youtube about running nodes for some new projects, how good is this over mining crypto?.
Your question is general and I will try to answer it in detail for two types.
Proof of Work coins VS Proof of Stake coins. ( POW VS POS)
Proof of Work:
Running a node in Bitcoin is not profitable and its purpose is to enhance privacy more than profit.
To manage the node, you need enough memory space and a fast internet to synchronize all the blocks and broadcast your transactions in the future without the need for a third party.
It is a different behaviour from mining, which is considered profitable.
The same concepts are shared by most Proof of Work currencies.
Proof of Stake:
The matter here differs according to how the new blocks are produced, some of which give stackers some coins, and the amount of profit depends on the amount of money you have.