Antibiotics Linked To Increased Risk of Kidney Stones

[BADecker]

And loads of additional info besides kidney stones.


Antibiotics Linked To Increased Risk of Kidney Stones


https://www.lewrockwell.com/2023/07/joseph-mercola/antibiotics-linked-to-increased-risk-of-kidney-stones/
According to research1 published in the Journal of the American Society of Nephrology (JASN) in 2018, oral antibiotics are a risk factor for kidney stones. Health records for 13 million children and adults in the U.K. were reviewed, showing that exposure to five classes of oral antibiotics were associated with kidney stones within three to 12 months post-use. The adjusted odds ratio of kidney stones was:

• 1.27 for broad-spectrum penicillin

• 1.67 for fluoroquinolones

• 1.70 for nitrofurantoin/methenamine

• 1.88 for cephalosporins

• 2.33 for sulfas

The association was most pronounced among younger children and remained statistically significant for up to five years after exposure, with the exception of broad-spectrum penicillin. The authors concluded that:2

"Oral antibiotics associated with increased odds of nephrolithiasis [kidney stones], with the greatest odds for recent exposure and exposure at younger age. These results have implications for disease pathogenesis and the rising incidence of nephrolithiasis, particularly among children."

Kidney Stones in Children Are on the Rise

If this link is true, then we'd expect to see rising rates of kidney stones in young patients, and that's precisely what we're seeing. As reported by NBC News, July 8, 2023,3 data show kidney stones are "now occurring in younger people, particularly among teenage girls," and "diets high in ultraprocessed foods" and "increased use of antibiotics early in life" are thought to be among the key contributors to this trend.

Between 1997 and 2012, kidney stones during childhood doubled.

According to research4 published in the Clinical Journal of the American Society of Nephrology in 2016, between 1997 and 2012, the mean annual incidence of kidney stone disease across age groups increased 1% annually, from 206 to 239 per 100,000 persons.

The highest increase was seen in 15- to 19-year-olds, among whom the incidence rate increased 26% per 5 years. Within this age group, incidence was 52% higher among girls. In men, kidney stones became more common after age 25. According to the authors:5

"These changes in incidence resulted in doubling of the risk of nephrolithiasis during childhood and a 45% increase in the lifetime risk of nephrolithiasis for women over the study period."

Oral Antibiotics Associated With Inflammatory Bowel Disease

As noted by the JASN authors,6 previous studies have found an association between oral antibiotics and inflammatory bowel disease (IBD), which is thought to be due to a disruption of gut microbiome.

In May 2022, research7 linking oral antibiotics and IBD was presented at the Digestive Disease Week conference in San Diego, California. Here, the researchers analyzed the health records of more than 2.3 million older adults, aged 60 to 90, who were part of the Danish National Patient Register and the Danish National Prescription Register.

On average, use of antibiotics was associated with a 64% increased risk of developing IBD, and the risk increased with additional doses.8 Compared with those who had taken no antibiotics in the previous five years:9

• One prescription for antibiotics was associated with a 27% increased risk of IBD

• Two prescriptions increased risk by 55%

• Three prescriptions increased risk by 67%

• Four prescriptions increased risk by 96%

• Five or more prescriptions increased risk by 236%

Adults who had been prescribed antibiotics one to two years prior to IBD diagnosis had the highest risk. And, while all classes of antibiotics were associated with increased IBD risk, fluoroquinolones, which include brand names Cipro and Levaquin, had the strongest association.10

Interestingly, a very recent study that was just published found that niacinamide may be very useful in the treatment and prevention of IBD11 by converting to NAD+ as a cofactor to produce more ATP in the mitochondria. I have written two reviews that discussed the many other benefits of niacinamide to increase NAD+.

Fluoroquinolones Linked to Fatal Heart Condition

Fluoroquinolones, which are frequently prescribed for upper respiratory infections and urinary tract infections (UTIs) have also been shown to harm your heart. In December 2018, the U.S. Food and Drug Administration issued a safety announcement12 about fluoroquinolones after four studies linked the antibiotic to an increased risk of tears in the aorta (aortic dissection), which can be fatal.13

The aorta is the main artery in your body supplying oxygenated blood to your circulatory system. The artery comes from the left side of your heart and runs down the front of your backbone. The review by the FDA found fluoroquinolone antibiotics increase the risk of rupture following an aortic aneurysm (i.e., enlargement of the aorta to more than 1.5 times its normal size).

The finding led the FDA to caution against the use of fluoroquinolone antibiotics in those at risk unless there are no other treatment options available. Specifically, the antibiotic should not be used by:

• Those who are at risk for aortic aneurysm

• Those suffering peripheral atherosclerotic vascular disease or high blood pressure

• The elderly

• Those with Ehlers-Danlos syndrome or Marfan syndrome (genetic disorders)

Antibiotics Linked to Colorectal Cancer

Researchers have also linked the use of antibiotics to an increased risk of colorectal cancer. As reported by Live Science in 2014:14

"… researchers looked at the medical records of more than 22,000 colorectal cancer patients in the United Kingdom, and followed them for an average of six years … The researchers compared the amount of antibiotics the patients had taken at least six months before being diagnosed with cancer, to the amount of antibiotics taken by a group of about 86,000 healthy people.

After controlling for known risk factors for colorectal cancer — including obesity, diabetes, smoking and alcohol consumption — the results showed people who had taken antibiotics, including penicillins, quinolones and metronidazole, were 8% to 11% more likely to develop colorectal cancer … possibly through the effects of the drug on colon bacteria …"

A 2016 study15 also concluded that use of antibiotics was associated with an increased risk of colorectal cancer, especially when used frequently, and research16 published in 2017 found that women who had used antibiotics for two months or more were at an increased risk of developing colon polyps, which can be a precursor to colorectal cancer.

Those who used the drugs for a total of at least two months in their 20s and 30s had a 36% increased risk of polyps compared to those who did not, and women who used them for at least two months in their 40s and 50s had a 69% increased risk.

Antibiotics Fuel Chronic Disease by Decimating Your Microbiome

In the article I wrote in February of this year "The New Endangered Species: The Human Gut Microbiome," I reviewed the documentary film "The Invisible Extinction," which highlights the work of microbiologists Dr. Martin Blaser and Gloria Dominguez-Bello, who are investigating the links between chronic diseases and the loss of bacterial diversity in the human gut.

Overuse of antibiotics is a major driver of this loss. Elective C-sections and processed foods also contribute to the destruction of our microbiome. According to research published in the Cleveland Clinic Journal of Medicine in 2018,17 Americans have already lost half of their microbial diversity, which is why the risks of antibiotics must be carefully weighed against the benefits prior to use.

Many 'Health Foods' Also Contribute to Kidney Stones

As mentioned, diet can also play a significant role in kidney stone development, and processed foods aren't the only culprits. Oxalate (oxalic acid with calcium attached) account for about 80% of all kidney stones, and high-oxalate foods such as spinach, Swiss chard and beet greens are touted as "superfoods."

Another high-oxalate food is almonds, which you can easily "overdose" on if you're eating bread made with almond flour or drinking almond milk, or if you're on a keto or paleo diet, as they both tend to rely heavily on almonds. Other foods high in oxalate include peanut butter, wheat bran, potatoes, rice bran and dark chocolate.

If you're prone to kidney stones, these are all foods that need to be avoided as much as possible. High-oxalate foods can also contribute to many other troublesome health problems, as discussed in my December 2022 interviewed with Sally Norton, author of "Toxic Superfoods."

For example, aside from calcium oxalate kidney stones, other symptoms you might experience if you're exposed to excessive amounts of oxalate include:
...

[Queentoshi]

Antibiotics Linked To Increased Risk of Kidney Stones

Asides the fact that there will be some dangerous or substandard antibiotics that will be circulating the market, antibiotics are a category of drugs that I have always known should not be abused or taken too frequently because of how powerful they are. Many people do not know this and have not been told the dangers of using antibiotics excessively, so at the slightest symptom and because of how available antibiotics are to them, they abuse it and take it even without the prescription from the doctor. All these drugs have an effect on the Kidney, maybe this is a reason it is now linked to kidney stones.

[DeathAngel]

I think a medical professional would judge the risk vs reward when assessing a patient with the idea of potentially prescribing antibiotics. If a young person is admitted to hospital with a bad infection & potential sepsis then they are not even going to consider any future likelihood of kidney stones. The doc is going to pump antibiotics into the young person to save their life. A doc will always consider the positives vs negatives before deciding which course of action to take.

[Zlantann]

I think a medical professional would judge the risk vs reward when assessing a patient with the idea of potentially prescribing antibiotics. If a young person is admitted to hospital with a bad infection & potential sepsis then they are not even going to consider any future likelihood of kidney stones. The doc is going to pump antibiotics into the young person to save their life. A doc will always consider the positives vs negatives before deciding which course of action to take.

Almost every drug we use has side effects. That is why it is more important to prevent diseases than to cure them because curing is more expensive and risky. For some time now I have considered using home remedies to cure some sickness in other to avoid the risks associated with chemical drugs and their effect on some vital organs in the body. But these homemade drugs from local leaves and roots seem to be ineffective in tackling some infections.

But like DeathAngel said the doctor has to consider the advantage and disadvantages of administering the drugs. If the advantage outweighs the negative effect, the medical practitioner will have no other option than to administer the drugs.

Kidney Stones in Children Are on the Rise

I thought kidney stone was a product of dehydration and the simple solution to it is to ensure the sufferer takes in more water. I know that there have been an increase in diabetics among children in my country due to artificial food that is making them obese but the issue of drugs causing kidney stone is fearful. There should be an alternative way of avoiding these antibiotics.

[BADecker]

I think a medical professional would judge the risk vs reward when assessing a patient with the idea of potentially prescribing antibiotics. If a young person is admitted to hospital with a bad infection & potential sepsis then they are not even going to consider any future likelihood of kidney stones. The doc is going to pump antibiotics into the young person to save their life. A doc will always consider the positives vs negatives before deciding which course of action to take.

That's part of the reason why doctors still vigorously administer the covid vaxx, even though they know that it has killed thousands, and is still killing more, right?

[Gyfts]

Antibiotics Fuel Chronic Disease by Decimating Your Microbiome

In the article I wrote in February of this year "The New Endangered Species: The Human Gut Microbiome," I reviewed the documentary film "The Invisible Extinction," which highlights the work of microbiologists Dr. Martin Blaser and Gloria Dominguez-Bello, who are investigating the links between chronic diseases and the loss of bacterial diversity in the human gut.

Overuse of antibiotics is a major driver of this loss. Elective C-sections and processed foods also contribute to the destruction of our microbiome. According to research published in the Cleveland Clinic Journal of Medicine in 2018,17 Americans have already lost half of their microbial diversity, which is why the risks of antibiotics must be carefully weighed against the benefits prior to use.

This can be mitigated by taking probiotics with antibiotics. Over prescription of antibiotics is more of an issue than what the side effects of antibiotics are. If the pharma industry isn't careful, they'll end up making strains that are resistant to all the known antibiotics.

That's what happened to penicillin during the WW2 era where a selection mechanism bred bacterial superbugs. It isn't particularly profitable for the pharma companies to pour hundreds of millions into developing antibiotics either -- not many novel antibiotics are in the pharma R&D pipeline.

[Gozie51]

Almost every drug we use has side effects. That is why it is more important to prevent diseases than to cure them because curing is more expensive and risky. For some time now I have considered using home remedies to cure some sickness in other to avoid the risks associated with chemical drugs and their effect on some vital organs in the body. But these homemade drugs from local leaves and roots seem to be ineffective in tackling some infections.

Like you admitted that all drugs have side effects, I believe you are referring to chemical drugs but those chemical drugs are also formulated from same local leaves, herbs and roots. In order words, home remedies of leaves herbs or roots also have effects.

One of the disadvantages of herbs and roots etc are that they don't have dosage. The human body varies and you have to scientifically know what body size takes what like in chemical drugs where there is classification of different levels of age to take a particular dose. So that is one major challenge of medicine not medically and scientifically proven. If you take an abnormal dose of home remedies, same organs are in trouble.

[yhiaali3]

The saddest thing about the study was the children whose incidence of kidney stones increased because of the antibiotics. It's really sad to see young children with this type of disease so early in their life.

Pharmaceutical companies in general promote antibiotics in a big way, regardless of the many bad side effects of these antibiotics.

Parents should take their part in such cases and try not to give their children antibiotics unless absolutely necessary.

[BADecker]

Almost every drug we use has side effects. That is why it is more important to prevent diseases than to cure them because curing is more expensive and risky. For some time now I have considered using home remedies to cure some sickness in other to avoid the risks associated with chemical drugs and their effect on some vital organs in the body. But these homemade drugs from local leaves and roots seem to be ineffective in tackling some infections.

Like you admitted that all drugs have side effects, I believe you are referring to chemical drugs but those chemical drugs are also formulated from same local leaves, herbs and roots. In order words, home remedies of leaves herbs or roots also have effects.

One of the disadvantages of herbs and roots etc are that they don't have dosage. The human body varies and you have to scientifically know what body size takes what like in chemical drugs where there is classification of different levels of age to take a particular dose. So that is one major challenge of medicine not medically and scientifically proven. If you take an abnormal dose of home remedies, same organs are in trouble.

Still waiting for government to label all food with: "The Surgeon General has determined that food is hazardous to your health."

[Gozie51]

Still waiting for government to label all food with: "The Surgeon General has determined that food is hazardous to your health."

Hahaha the government does not need to label any food as hazardous but based on the health effect of some food, you know some things you put inside your body can cause more damage than they are doing you good. Depending on your age, doctors and health officials have identified that as the age increase so also the limitation of some food, for example sugary foods, processed foods, red meat or smoked type of meat, eggs.

[BADecker]

Still waiting for government to label all food with: "The Surgeon General has determined that food is hazardous to your health."

Hahaha the government does not need to label any food as hazardous but based on the health effect of some food, you know some things you put inside your body can cause more damage than they are doing you good. Depending on your age, doctors and health officials have identified that as the age increase so also the limitation of some food, for example sugary foods, processed foods, red meat or smoked type of meat, eggs.

We all need to strongly remember one major thing that Covid taught us. Well over 500,000 people died in the US alone from doctor-recommended Covid protocols, including but not limited to the vaxx. And millions more died around the world from the same. Some sources suggest 2 billion died. And it is the doctors who can't agree on the numbers... because some of the doctors are more honest than other of the doctors.

So, listen to the doctors just to see what they have to say, but then look for other, better information from elsewhere.