At the abstract generative essence level, there are two salient points he makes:
1. Ubiquitous technology disintermediates (transcends) Coasian barriers such as governments and geopolitical circumstance.
2. Decentralized consensus is a monumental paradigm shift.
However, I assert that:
1. Without anonymity, fragmentation and Coasian barriers will persistent (find my recent posts about anonymity).
2. Decentralized consensus is often not the correct way to implement decentralized services[1].
3. Ethereum has the wrong model for a programmable block chain (find my recent post for the correct model).
P.S. Charles and I used to talk before he found Vitalik and got involved with Ethereum.
[1] Two examples are that MaidSafe and StorJ are not the correct way to implement decentralized hosting as I have explained recently. And OpenBazaar is not the correct way to implement decentralized online selling. In both cases, and plethora of hidden services (servers) is the correct model and I predict it will win.