Ever since the 0.8.2 I have been having major issues with it. It takes hours to open the program and the laptop is practically unuseable.
Now I'm getting "system error: Database I/O error " that comes up whenever I open the program.
Also where has the bitcoin data directory moved to I can no longer find it in ~/library/application support/bitcoin because there is no bitcoin folder anymore....
Try installing the newest bitcoin client. If your referring to the bitcoin directory where the wallet.dat is located its by default in %appdata%/Roaming/Bitcoin