You will want the PCI-E extenders with molex if you hook up a lot of GPUs to a motherboard (greater than 4 if a good motherboard, or less if a junk one). The reason is they can pull 75W from the slot by spec (although cards usually pull most of their power from the PCI-E aux, you never know). I've seen pictures of
melted ATX plugs/motherboards from too much current going over a few wires and traces.
If you want to hook up 5 or 6 7950s, you would definitely want at least 2 or 3 of them hooked up with extenders that have a molex.
Also keep in mind you don't want to overload the molexes off your PSU. So try to use different chains...
EDIT: Here's one such story.
https://bitcointalk.org/index.php?topic=102890.0 I have seen others but don't have examples handy.