Noise wont be a problem, these cards are next to silent with the dual fans depending on the setup.
Heat well, if you want a sauna and to grow some tropical plants then it will be a perfect solution.
If you have been drinking too much, eating bad then you can sweat out the toxins and begin a cleansing program.
since he gonna put the rig in his office then it is a problem for him i guess .
i used 4x sapphire rx 480 nitro too and pretty noise enough for a silent room and of course heating , desolate and a little bit clumsy but looks like it could be a good idea to create some green area around to make the room more comfortable hmmm .