Closing the BTC-e will have a good impact on the course. Because this btc never go back in reality. I wonder what is the number of lost bitcoins, to which there is no access for one reason or another?
There are lots of Bitcoins permanently lost. Every year there are people that forget their private keys or send Bitcoins to the wrong address. There are people that die and no one knows they had Bitcoins or don't know how to access them. All these Bitcoins are permanently lost. The problem is that no one knows about many of the lost coins. Some may be known,but there is no way to know about all of them.
The total number of lost Bitcoins will just continue to increase over time. We can only approximate how many could be lost but just because some haven't moved doesn't mean they are lost. They could be just held for years as an investment.