This is a new install of MegaCoin on Windows 10 64.
Edit:
I just got some MEC. So the mining part does work but it seems to be only single threaded.
you can run the daemon.
If you want to use the qt wallet while mining, just clone the blockchain ($HOME/.megacoin ) from qt wallet to a different directory (wallet sould stopped when copy!)
no need to copy the wallet.dat if you use disablewallet in daemon.
run it:
./megacoind -datadir=/cloneddirpath -listen=0 -disablewallet -rpcthreads=XXXX
XXX = number of your cpus + 2
choose an address from qt wallet, and start mining to that:
./megacoin-cli -datadir=/cloneddirpath generatetoaddress 99999 YOURADDRESS 300000000
each calls "eat" one rpc threads, so use multiple times (=your cpu count)
you can control the daemon with last two rpc thread. (getnetworkhash, getmininginfo, stop)
you can start the qt wallet, and watch for your blocks.