Yes. Since SegWit2x has
no replay protection (not even opt-in replay protection anymore, perhaps for ideological reasons), you will have to take additional steps to ensure that your coins are secure before you can resume spending as normal.
You should read
this article to find out about what may be necessary if there remains no replay protection by the time of the fork.
However, it's possible that a solution will be created on one of the chains by the time of the fork, in which case you may have to participate in opt-in replay protections, or ideally do nothing at all.