no they don't run on usb, they use the cables of usb for the pci express lanes for data, its NOT the same thing. you cannot just plug the usb cable into any ol usb port and expect it to work. what a noob. you should really do research before asking such a dumb question. as matter of fact this very subject has been brought up before and guess what it was by someone like yourself that cared not to do research before asking
And that I understand but I can also change the pci to run on e sata i have a dual video card enclosure running at the moment by Alienware ... On a side note no need to be a dick I actually did try to search in here before asking the question and I know it's been mentioned that it will over heat but I have my laptop water-cooled because I overclocked it , so before you assume we are all idiots and you are a god be humble homie