I had a few instances where the chrome apps (Ledger Manager and Ledger Bitcoin wallet) won't detect an already connected and unlocked device, and I've had to disconnect the device and then reconnect and unlock for the chrome app to detect the device.
Also, Ledger Manager doesn't detect the device if you have an app "open" on the device itself... you need to be on the "main menu" that shows the "settings" app and all your installed apps.
At the moment, I don't seem to have any issues with the Ledger Bitcoin Wallet either... it is syncing up fine showing everything it should.
It is not working for me,my last transaction is not show in Ledger Bitcoin Wallet and I get message "Your wallet may not be up to date as the last synchronization did not complete successfully" and it is like that for last 2 days.I try to remove app from Chrome and install again,and also try to reset application data but nothing helps.
There is info on Ledger site "
We are currently experiencing synchronization issues with several wallets, please read this FAQ to understand the problem" but it seems that not all users affected with this API problem.
I can only say that I tried everything what is possible,but I can not send/receive and use my coins in last 48 hours...