Who has set up or is interested in setting up a masternode? And what coin(s) do you want to set up a masternode for?
Really hard to answer this question...
Sometimes, i would say for gambling, i pick a few new masternodes in the very early stage, this way my ROI can be very short, or on the another side, I can lose a high percentage of my investment
Most of the time, for long time investment im doing a really deep research on the masternode coin, then making the decision to invest or not invest money into that MN ...
If you jumping in on time to a
new coin masternode hosting, you can have your ROI within a very short period of time, but on the same time you are risking your investment, because its just really hard to say where the coin prices are going in the next days, weeks ...
Masternode tracking websites really not going to give you a accurate forecast about any brand new masternodes, bc they just can not, the coin is new, there is no way to track the coin past performance or give you a estimated forecast for future.
You have to dig deeper in the new coin issuer future plans,
background information,
what is ready for that coin ( exchange, block explorer, wallet ),
be sure at least they have a roadmap, whitepaper ready,
good sign if the issuer have some bounty program for future development,
the issuer have a great marketing team,
they representing themselves on different social media platforms,
they provide some kind of support ...
Better, more safe if you are investing into a few months, maybe a year old masternode, (after you did your own research and picked the coin you want) , this way you can see the estimated ROI for that investment, you can see where the price is stabilized... Stabilized masternodes estimated ROI going to be much much more longer for sure and seems like a much safer investment for longer time.