INOVATIVE BIORESEARCH ICO is the first launched by a Biotech Company. INNBC Token sale starts 1 May 2018. 20% discount at pre sale.
https://www.innovativebioresearch.com/pre-icoAlong with developing novel AIDS cure research and a Token (INNBC) backed by physical goods, with our ICO we are also developing the "You're not alone" app, which will act as a platform for all our products and services, as well as providing a decentralized database for clinical data. Let's focus today on the revolutionary blockchain implementation of our app.
The Limitations of Current Centralized Databases for Clinical DataTraditionally, all data generated by scientific research is collected in the form of a scientific article, which is published in a peer reviewed scientific journal, and it is usually made available on a public database such as the NIH’s pubmed database (
https://www.ncbi.nlm.nih.gov/pubmed). When a novel therapeutic strategy, such as our novel cell-based therapy for HIV, SupT1 cell infusion therapy, goes through the several stages of clinical research, different research teams all over the world may perform the research. And once the therapy is finally approved for human treatment, different clinicians all over the world may administer the treatment to patients. This means that when a research team wants to perform clinical research, they have to go through the tedious and time consuming process of searching for all the published data from previous trials, read all the papers, select the useful data, and make the best possible interpretation of the data to create a protocol for their trial, personalizing it for their typology of patients. In fact, every patient may have different individual characteristics (e.g., age, ethnicity, HIV tropism) and thus may require personalized treatment protocols. And the same issue is present when clinicians begin to administer an approved treatment to patients; they have to go through all the papers and make a best guess on what treatment protocol should be used. As mentioned, this process of accessing clinical data can be quite tedious and time consuming, but it can also introduce human error.
A Possible Solution: A Decentralized Database Using the Blockchain to Store and Access Clinical DataA possible solution to the challenge posed by having to access clinical data from the current ancient system could be provided by the creation of a decentralized database for clinical data using the blockchain technology. The “You’re not alone” app will feature a user-friendly interface allowing any clinician running a clinical investigation to enter the data produced by their trials. The application will allow the input of a broad range of individual parameters for each treated patient, such as age, ethnicity, disease progression stage, viral tropism of HIV virus carried, along with the clinical protocol used (e.g., dosage of SupT1 cells infused each week) and the outcome of the treatment (e.g., viral load, CD4+ T cell count). The app will then access and elaborate the data on the fly; statistical analysis (means, standard deviations, correlations, power) and even the elaboration of suggested treatment profiles that could work best for each type of patient could be performed. This would take away the burden of having to manually search and process all the data as in the current centralized databases. And such an application would have an infinite potential for growing. For instance, an amazing feature could be to store in the database the genotypic information of the HIV virus carried by each patient, allowing to keep track of all mutations and genetic modifications caused by the treatment as well as the resulting viral phenotypic changes. Therefore, such a database would be constantly growing and evolving as new parameters are added to it, and it would be always available, anytime, anywhere, and to anyone connected. Such an app would help speed up tremendously the clinical development stages of our AIDS cure research; it could be a game changer.
In summary, these are some of the specific advantages of using the blockchain technology for creating a decentralized database for clinical data•Immutability. Scientific data need to be immutable. Once a study is peer reviewed and published, its data must be permanently stored and never altered. In the blockchain, all data is stored in every single node, never ceasing to exist, and always staying on the blockchain. It is immutability that gives the blockchain its openness and BFT (Byzantine Fault Tolerance).
•Decentralization. The blockchain is designed to be distributed and synchronized across networks, making data freely available to anyone. We believe that scientific data should be shared and not being hidden behind a firewall. Decentralization is essential to hand over administrative authority from central institutions managing the data, such as governments and private entities, to the collectivity. In fact, if a database is controlled by one single entity, being it a private entity or government, it means that such entity has total control over the database, and such control can be influenced by personal conflicts of interests. Therefore, decentralization is the only way to ensure that scientific data become public property.
•Security. The kind of transactions that can be performed are strictly defined in advance and stored in the blockchain as “smart contracts”; this prevents fraudulent data from being added to the blockchain thus ensuring integrity of the database. By contrast, it would be much easier to compromise a centralized database. In addition, in terms of costs, creating an infrastructure ensuring the same level of data integrity protection of a smart contract deployed on the Etherum blockchain, which is basically impossible to compromise, and most importantly, maintaining such a platform up and running, would simply not be feasible.
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