I have 2 of the same mobo.
Not sure the problem with yours...I installed 5 cards all at once, installed drivers and ran it.
Maybe your PSU? What OS? What driver version? Do you have ALL the MSI drivers installed?
Running linuxcoin.. Doesn't even get to that point though. Can't enter bios with the 3rd card inserted. PSU is a 1000w ocz.. I'm running 3 6870's should be more than enough wattage.
I run Win7 but at the initial boot point it shouldn't matter. Which slots are you using on the mobo?
Hey man just did some switching and swapping still can't figure out whats wrong. So apparently the third card doesn't even matter. If the 2nd card isn't in the right slot it wont start either.
I have a card in slot 1.. works. Slot 3 works. If I put another card in anything other than slot 3 it will boot up to a black screen with blinking cursor. Got 2 running but I have another card sitting here and would love to get it running. I'll never buy one of these motherboards again thats for sure.
Check the manual for the Mobo, do a BIOS reset, try to boot from scratch with all cards installed at the same time (slots 1-3-5). If that doesn't work RMA the board or call MSI directly and see if the techs can help out. I have 2 of those same boards and one of my friends has another one...I would say its one of the most widely used mining boards for 4+ GPU setups...you may just have got a bad one.