I'm running 13 RX 480/580 8GB on Windows v1709 with the Adrenaline v18.71 drivers on a ASRock H110 Pro BTC+ moterboard with an i3 CPU, 8GB RAM and a 78 GB vitrual memory set. Windows does start to run a bit laggy when running more than 10 GPU's, but it's not too bad and otherwise runs stable.
Do a clean install of Windows 1709 with only a single GPU in the primary x16 PCI-E slot. After the install is finished, on the first logon disable Windows feature updates in gpedit. On Windows 10 Pro you can set a Group Policy to defer feature updates until they have been targeted for business deployment, which is about 4 months after the public release, or you can also defer feature updates for up to 365 days. This way you still get the security updates.
gpedit ==> Computer Configuration ==> Administrative Templates ==> Windows Components ==> Windows Updates ==> Windows Update for Business ==> Select when Preview Builds and Feature Updates are Received ==> Set to 'enabled' and in the drop down select 'Semi-Annual Channel'.
Then run Windows Update to get the latest updates and reboot. Go back in to gpedit and disable driver updates to keep Windows Update from modifying your drivers.
gpedit ==> Navigate to: Computer Configuration ==> Administrative Templates ==> Windows Components ==> Windows Update and set 'Do not include drivers with Windows Update' to enabled.
Download the latest driver for your GPU's and run DDU in safe mode to remove the Windows installed driver and disable automatic driver installation when prompted by DDU. Shutdown, install the rest of the GPU's and then run the GPU driver setup. After the driver setup is finished (it will take >20 minutes with 13 cards). If you have any RX 570 or 480 cards with a modded Bios you will also need to run the pixel patcher to disable the driver signature check.
https://www.monitortests.com/forum/Thread-AMD-ATI-Pixel-Clock-PatcherI also go in to Windows Apps from the settings to uninstall all the extra Windows crapware and disable all the Windows spyware in the Privacy settings.