You will be able to use all RPCs. However, those that require pulling information from stored block data will not be able to give you data from blocks that have been pruned. For example, getblock will read a block off disk and give it to you decoded. If you use getblock on a block that has been pruned, it will give you an error. For blocks that were not pruned, it will work as expected.
Although pruning deletes old blocks from disk, there is still data kept about them in the chainstate database. This includes the block header so getblockheader will still work.
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