When it comes to ambiance then it would pertain on a physical casino and nothing beats when it comes to pure gambling experience when you are with other people.
The noise, the chitchats and the crowd which would be entirely different when you are just playing in front of your pc
It works both ways actually
Some people are just shy of other people, and thus avoid crowds, gatherings, meetings, etc. For them online gambling is a godsend. Indeed, there are other people too. In fact, there are many different people across the world, and all of them have different preferences, compulsions and inclinations. So it can as well be said that nothing beats playing at home in a cozy armchair in front of your computer screen when no one looks over your shoulder and whispers some irrelevant bullshit in your ear