I think this is a good discussion I was curious too about where to open an online cryptocurrency Casino, it came to my mind lately but I really think there's a lot to consider including license, bankroll, development, marketing, maintenance, etc.
Yes if you want to do serious business then you need to keep these things properly planned in your mind.
First of all many people will ask you questions and about your trust, if you don't have a proper license.
After that, if you don't have enough bankroll then soon, the site will become bankrupt and no Gamblers will visit the site again.
At last maintenance and Promotions also plays a major role.
You need to give periodically updates with new features in the site/casino, that will keep your Gamblers attached to the site.
And a right way to Promote the casino will lead you to the top of the Gambling business.
Hope this helps you mate.