I played with worksize and aggression. Touching those setting usually optimize. I can't get the card to even start with reaper without a crash.
The difference between 300 memory and 800+ does take a toll. I'm guessing my PSU was at it's limit already. That's not to say that Reaper could REALLY use an update for efficiency. I'm thinking we'll be seeing a lot of those types of questions in the next few months.